PD22-01 ASSESSMENT OF THE RISK OF POOR RENAL FUNCTION RECOVERY AFTER TRANSPLANTATION USING MORPHOMETRIC CRITERIA IN A POPULATION OF OBESE AND OVERWEIGHT PATIENTS

Abstract

You have accessJournal of UrologyTransplantation & Vascular Surgery: Renal Transplantation & Vascular Surgery I (PD22)1 Apr 2020PD22-01 ASSESSMENT OF THE RISK OF POOR RENAL FUNCTION RECOVERY AFTER TRANSPLANTATION USING MORPHOMETRIC CRITERIA IN A POPULATION OF OBESE AND OVERWEIGHT PATIENTS Ugo Pinar*, Arthur Mageau, Xavier Rod, Yohann Renard, Jacques Irani, Benoit Barrou, and Thomas Bessede Ugo Pinar*Ugo Pinar* More articles by this author , Arthur MageauArthur Mageau More articles by this author , Xavier RodXavier Rod More articles by this author , Yohann RenardYohann Renard More articles by this author , Jacques IraniJacques Irani More articles by this author , Benoit BarrouBenoit Barrou More articles by this author , and Thomas BessedeThomas Bessede More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000000872.01AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Except for BMI and clinical exam, few tools can evaluate and predict kidney transplantation outcomes within obese patients population. Visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) are new tools to define obesity that have been poorly evaluated in kidney transplantation. Some studies suggest that the ratio VAT/SAT is correlated to post-transplantation graft function. The objective was to evaluate new morphometric markers of obesity to foresee graft function in kidney transplantation METHODS: A retrospective monocentric study from 2012 to 2017 included all patients with a BMI greater than 25 who had been transplanted. Based on a semi-automatic Hounsfield density detection sofware, the following measurements were performed on CT-scans section at L3 and L4 levels: Sub-cutaneous Adipose Tissue surface (SAT), Visceral Adipose Tissue surface (VAT), Vessel-to-Skin distance (VSK), Abdominal Perimeter (AP), Psoas surface, Skeletal Muscle Index (SMI). A univariate ROC-analysis was performed for each measure and for BMI. A multivariable logistic model of all the measurements was performed. Relevant variables were determined by the backward elimination procedure RESULTS: 248 patients were included. Their mean (SD) characteristics were: BMI = 29,68 (3,63) kg/m2, Age = 56,01 (12,67) years and cold ischemia time (CIT) = 15,4 (7,9). 14 patients (5,65%) had a primary graft failure and 69 patients (27,82%) had a delayed graft function. Bad graft function was significantly associated with BMI, VAT, SAT, AP, VSK and CIT. On multivariate analysis, SAT and VAT remained significant. The area under the curve (AUC) for a model including VAT, SAT and CIT was 0,69 (fig 1) CONCLUSIONS: VAT and SAT are associated with postoperative graft function in kidney transplantation within obese or overweight recipients. Combined in a morphometric tool, they were predictive of post-transplantation graft function. This model was more efficient than a model including BMI alone. Source of Funding: The authors declare no funding or conflicts of interests © 2020 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 203Issue Supplement 4April 2020Page: e459-e459 Advertisement Copyright & Permissions© 2020 by American Urological Association Education and Research, Inc.MetricsAuthor Information Ugo Pinar* More articles by this author Arthur Mageau More articles by this author Xavier Rod More articles by this author Yohann Renard More articles by this author Jacques Irani More articles by this author Benoit Barrou More articles by this author Thomas Bessede More articles by this author Expand All Advertisement PDF downloadLoading ...