PD10-11 COMPARISON OF SURVIVAL OUTCOMES FOR AFRICAN-AMERICAN AND CAUCASIAN MEN WITH ADVANCED PENILE CANCER IN FLORIDA

Abstract

You have accessJournal of UrologyGeneral & Epidemiological Trends & Socioeconomics: Quality Improvement & Patient Safety III1 Apr 2016PD10-11 COMPARISON OF SURVIVAL OUTCOMES FOR AFRICAN-AMERICAN AND CAUCASIAN MEN WITH ADVANCED PENILE CANCER IN FLORIDA Chad R. Ritch, Nicola Pavan, Samarpit Ray, Nachiketh Soodana-Prakash, Raymond R. Balise, Dipen J. Parekh, and Mark L. Gonzalgo Chad R. RitchChad R. Ritch More articles by this author , Nicola PavanNicola Pavan More articles by this author , Samarpit RaySamarpit Ray More articles by this author , Nachiketh Soodana-PrakashNachiketh Soodana-Prakash More articles by this author , Raymond R. BaliseRaymond R. Balise More articles by this author , Dipen J. ParekhDipen J. Parekh More articles by this author , and Mark L. GonzalgoMark L. Gonzalgo More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2016.02.2919AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Studies suggest that there may be disparity in clinical outcomes for African American men (AAM) compared to Caucasian men (CM) with penile squamous cell carcinoma (SCC). We sought to determine whether there was a survival difference for African American versus Caucasian men, particularly in locally advanced and metastatic cases of penile SCC where disease mortality is highest. METHODS Using the Florida Cancer Data System, we identified men diagnosed with penile SCC, from 2004 to 2014. We excluded men who were diagnosed on autopsy or at the time of death and with < 6 months of follow up. Demographic variables including: age, follow up, stage, race and treatment type were compared between AAM and CM. Treatment type was categorized as surgery alone or surgery plus additional therapy (chemotherapy and/or radiation). For locally advanced and metastatic disease, we compared treatment type and overall survival (OS) between AAM and CM. A multivariable model was developed to determine significant predictors of OS. RESULTS Of the 653 men with penile SCC, 198 [38 (19%) AAM and 160 (81%) CM] had locally advanced and/or metastatic disease. Median follow up for the entire cohort was 12.5 mos. For all stages, AAM demonstrated a significantly decreased median OS compared to CM (26 vs. 37 mos, p=0.03). For locally advanced and metastatic disease, there was a persistent, but non-significant, trend toward disparity in median OS between AAM and CM (17 vs. 23 mos, p=0.06). Fewer AAM compared to CM received surgery plus additional therapy for locally advanced and/or metastatic disease [8 (21%) vs. 42 (26%)], but this difference was not statistically significant. After adjusting for age, stage, and treatment type, AAM had increased likelihood of death from penile SCC (HR 1.63, p=0.015). CONCLUSIONS Mortality rates from penile SCC remain high in contemporary series. For AAM in Florida, advanced stage at presentation, along with treatment disparity, may partially explain decreased survival rates. Further studies are needed to determine the additional socioeconomic, as well as potential biologic, factors that may predict the relatively poor outcome observed in AA men with penile SCC. © 2016FiguresReferencesRelatedDetails Volume 195Issue 4SApril 2016Page: e243-e244 Advertisement Copyright & Permissions© 2016MetricsAuthor Information Chad R. Ritch More articles by this author Nicola Pavan More articles by this author Samarpit Ray More articles by this author Nachiketh Soodana-Prakash More articles by this author Raymond R. Balise More articles by this author Dipen J. Parekh More articles by this author Mark L. Gonzalgo More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...