PD09-12 SIGNIFICANCE OF PREOPERATIVE BUTYRYLCHOLINESTERASE AS AN INDEPENDENT PREDICTOR OF BIOCHEMICAL RECURRENCE-FREE SURVIVAL IN PATIENTS WITH PROSTATE CANCER TREATED WITH RADICAL PROSTATECTOMY

Abstract

You have accessJournal of UrologyProstate Cancer: Detection & Screening II1 Apr 2016PD09-12 SIGNIFICANCE OF PREOPERATIVE BUTYRYLCHOLINESTERASE AS AN INDEPENDENT PREDICTOR OF BIOCHEMICAL RECURRENCE-FREE SURVIVAL IN PATIENTS WITH PROSTATE CANCER TREATED WITH RADICAL PROSTATECTOMY Takuya Koie, Chikara Ohyama, Atsushi Imai, Shingo Hatakeyama, Takahiro Yoneyama, Yasuhiro Hashimoto, Tohru Yoneyama, and Yuki Tobisawa Takuya KoieTakuya Koie More articles by this author , Chikara OhyamaChikara Ohyama More articles by this author , Atsushi ImaiAtsushi Imai More articles by this author , Shingo HatakeyamaShingo Hatakeyama More articles by this author , Takahiro YoneyamaTakahiro Yoneyama More articles by this author , Yasuhiro HashimotoYasuhiro Hashimoto More articles by this author , Tohru YoneyamaTohru Yoneyama More articles by this author , and Yuki TobisawaYuki Tobisawa More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2016.02.2907AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Butyrylcholinesterase (BChE) is an alpha-glycoprotein found in the nervous system and liver. Its serum level is reduced in many clinical conditions, such as liver damage, inflammation, injury, infection, malnutrition, and malignant disease. In this study, we analyzed the potential prognostic significance of preoperative BChE levels in patients with prostate cancer (PCa) undergoing radical prostatectomy (RP). METHODS We retrospectively evaluated 931 patients with PCa who underwent RP from 1996 to 2014 at a single institution. Serum BChE was routinely measured in all patients before operation. Covariates included age, preoperative laboratory data (prostate-specific antigen [PSA], hemoglobin, total protein, albumin, BChE, lactate dehydrogenase, C-reactive protein,), clinical T (cT), biopsy Gleason score, D’Amico risk classification, and RP with/without neoadjuvant therapy. Univariate and multivariate analyses were performed to identify clinical factors associated with biochemical recurrence-free survival (BRFS). Univariate analyses were performed using the Kaplan-Meier and log-rank methods, and the multivariate analysis was performed using a Cox proportional hazard model. RESULTS The median BChE level was 255 U/L (normal range 168–470 U/L). The median age of the enrolled patients was 68 years, and the median PSA level at diagnosis of PCa was 8.39 ng/mL. The median follow-up period was 65 months. The 5-year BRFS rate was 72.9%. The 5-year BRFS rates in the BChE = 168 and = 167 U/L groups were 77.7% and 55.0%, respectively (P < 0.001). In the univariate analysis, BChE, cT, biopsy Gleason score, and D’Amico risk classification were significantly associated with BRFS. Multivariate analysis revealed that BChE was significantly associated with BRFS. CONCLUSIONS This study validated preoperative serum BChE levels as an independent prognostic factor for PCa after RP. © 2016FiguresReferencesRelatedDetails Volume 195Issue 4SApril 2016Page: e238 Advertisement Copyright & Permissions© 2016MetricsAuthor Information Takuya Koie More articles by this author Chikara Ohyama More articles by this author Atsushi Imai More articles by this author Shingo Hatakeyama More articles by this author Takahiro Yoneyama More articles by this author Yasuhiro Hashimoto More articles by this author Tohru Yoneyama More articles by this author Yuki Tobisawa More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...