Abstract
Background:MNS glycophorin variants such as glycoprotein (GP.) Mur, GP.Hop, GP.Bun, GP.HF, GP.Hut, and GP.Vw are known to carry multiple antigens, including Mia (MNS7). In East and Southeast Asians, an antibody to Mia is not only commonly found, but also clinically significant. Purpose and Methods: In this study, deoxyribonucleic acid (DNA) samples from 47 patients suspected of having anti-Mia by serological screening were genotyped for GP.Mur, GP.Hop, GP.Bun, GP.HF, GP.Hut, and GP.Vw variants using polymerase chain reaction (PCR) assay. Results: All patients were found to be negative for the presence of Mia-positive glycophorin variants. Conclusions: The presence of anti-Mia cannot be excluded in patients studied, as genotyping shows that Mia-positive MNS glycophorin variants are not present. Bangladesh Journal of Medical Science Vol. 21 No. 02 April’22 Page : 432-437
Highlights
The MNS blood group system (ISBT 002) was discovered after the ABO blood group system (ISBT 001)and before the Rhesus (Rh) blood group system (ISBT 004)[1]
The MNS system consists of 49 antigens that are the products of glycophorin A (GPA), glycophorin B (GPB) or hybrids thereof and are fully developed at birth[1,2,3].The genes encoding GPA (GYPA) and GPB (GYPB) are highly homologous with 95.5% sequence similarity[4]
The antibody was alsodetected in 0.05% (n=10/20,786) of blood donors in Thailand9and anti-Mia/Mur was detected in 0.1% (n=19/20,283) of patients in China[11]
Summary
The MNS blood group system (ISBT 002) was discovered after the ABO blood group system (ISBT 001)and before the Rhesus (Rh) blood group system (ISBT 004)[1]. There have been reports of hemolytic transfusion reaction (HTR) and hemolytic disease of the fetus and new born (HDFN) as a result of antibodies to MNS glycophorin variants, including anti-Mia[1,5,6]. The antibody was alsodetected in 0.05% (n=10/20,786) of blood donors in Thailand9and anti-Mia/Mur was detected in 0.1% (n=19/20,283) of patients in China[11]. MNS glycophorin variants such as glycoprotein (GP.) Mur, GP.Hop, GP.Bun, GP.HF, GP.Hut, and GP.Vw are known to carry multiple antigens, including Mia (MNS7). Purpose and Methods: In this study, deoxyribonucleic acid (DNA) samples from 47 patients suspected of having anti-Mia by serological screening were genotyped for GP.Mur, GP.Hop, GP.Bun, GP.HF, GP.Hut, and GP.Vw variants using polymerase chain reaction (PCR) assay. Results: All patients were found to be negative for the presence of Mia-positive glycophorin variants. Conclusions: The presence of anti-Mia cannot be excluded in patients studied, as genotyping shows that Mia-positive MNS glycophorin variants are not present.
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
