Abstract
This study was conducted to gather data from the literature on health state utility values (HSUVs) relevant to triple-negative breast cancer (TNBC) patients. Two systematic literature reviews (SLRs) were completed in April 2019, one to identify studies measuring health-related quality of life (HRQoL) outcomes and the other to identify economic studies in TNBC patients. The SLRs covered EMBASE, MEDLINE, EconLit, and CENTRAL as well as conference proceedings and health technology assessment (HTA) databases. Of the 4 bibliographic databases (2007-2019), 7 congresses (2017-2019), and 11 HTA databases (2007-2019) reviewed, 4 studies that reported HRQoL outcomes and 9 studies that reported economic outcomes were identified. None of the included HRQoL studies reported HSUVs in TNBC patients. Of the 9 economic studies identified, 4 (a value of information analysis, two cost-utility analyses, and an HTA submission) included HSUVs. In all 4 studies, the utility values were derived from published literature on the general breast cancer (BC) population. The utilities values reported were associated with a variety of health states. In the HTA submission, the mean utility values derived using a standard gamble technique for progression-free survival, response, stable disease, and progressive disease associated with metastatic BC were 0.73, 0.81, 0.65, and 0.45, respectively. The other economic evaluations used utility estimates for relapse (0.73), disease-free/well (0.78-1.0), and breast cancer in general (0.77). The methods for selection and synthesis of these HSUVs were not well-reported in the economic analyses. An SLR employing a highly sensitive search strategy for humanistic burden did not identify any HSUVs in TNBC patients. Existing economic models for TNBC employ utilities for different health states in the general breast cancer population; further research is necessary to derive HSUVs specific to TNBC that can be used in economic evaluations.
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