PC180. Incidence and Clinical Characteristics of Deep Vein Thrombosis (DVT) After Total Knee Arthroplasty (TKA) with DVT Chemoprophylaxis

Abstract

Objective: Deep vein thrombosis (DVT) after total knee arthroplasty (TKA) is very common and leading cause of death due to this procedure. The objective of this study was to investigate the in- cidence and clinical characteristics of DVT after TKA with DVT chemoprophylaxis. Methods: This is a prospective cohort study in single institution. The patients received postoperative DVT chemo- prophylaxis (low molecular weight heparin (LMWH) or Fondaparinux), followed by duplex ultra- sonography to check for DVT 1 - 2 weeks after TKA. The clinical characteristics were summarized and analysed by chi-square test and regression analysis. Results: Five hundred and thirty four pa- tients were enrolled from January 2007 to December 2010. DVT chemoprophylaxis was adminis- tered in 524 (98.1%) of the 534 patients. DVT occurred in 9 subjects (1.69%); 8 subjects had DVT in the leg, and 1 subject had a pulmonary embolism. Among them, asymptomatic DVT was ob- served in 5 patients (0.94%). Univariate analysis showed that surgical methods (revision, P = 0.0007), body mass index (BMI) (>25, P = 0.0028), low platelet count (less than 150 × 10 3 , P = 0.0219), time in the intensive care unit (ICU) (P < 0.0001), no administration of prophylactic LMWH (P = 0.0392), and a history of DVT (P < 0.0001) were significant risk factors of DVT. Conclu- sions: The incidence of DVT was 1.69% after TKA with prophylactic antithrombotic therapy. Revi- sion surgery, BMI, low platelet count, time in ICU, absence of prophylactic LMWH and history of DVT were significant risk factors of DVT. * Corresponding author.