Abstract
The patterns of CD8 T-cell epitopes recognized within the E6 protein in women who had cleared their human papillomavirus 16 infection were examined. T-cell lines were established using autologous dendritic cells infected with a recombinant vaccinia virus. Evidence of potential antigenic epitopes was shown in 8 of 23 (34.8%) women.
Highlights
The patterns of CD8 T-cell epitopes recognized within the E6 protein in women who had cleared their human papillomavirus 16 infection were examined
T-cell lines were established using autologous dendritic cells infected with a recombinant vaccinia virus
In a previously published study (6), we examined the role of cytotoxic T lymphocytes (CTL) in clearing human papillomavirus (HPV) 16 infection in women without evidence of precancer or squamous intraepithelial lesion
Summary
The patterns of CD8 T-cell epitopes recognized within the E6 protein in women who had cleared their human papillomavirus 16 infection were examined. T-cell lines were established using autologous dendritic cells infected with a recombinant vaccinia virus. In a previously published study (6), we examined the role of cytotoxic T lymphocytes (CTL) in clearing HPV 16 infection in women without evidence of precancer or squamous intraepithelial lesion.
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