Abstract
Image-guided prostate interventions often require the registration of preoperative magnetic resonance (MR) images to real-time transrectal ultrasound (TRUS) images to provide high-quality guidance. One of the main challenges for registering MR images to TRUS images is how to estimate the TRUS-probe-induced prostate deformation that occurs during TRUS imaging. The combined statistical and biomechanical modeling approach shows promise for the adequate estimation of prostate deformation. However, the right setting of the biomechanical parameters is very crucial for realistic deformation modeling. We propose a patient-specific deformation model equipped with personalized biomechanical parameters obtained from shear wave elastography to reliably predict the prostate deformation during image-guided interventions. Using data acquired from a prostate phantom and twelve patients with suspected prostate cancer, we compared the prostate deformation model with and without patient-specific biomechanical parameters in terms of deformation estimation accuracy. The results show that the patient-specific deformation model possesses favorable model ability, and outperforms the model without patient-specific biomechanical parameters. The employment of the patient-specific biomechanical parameters obtained from elastography for deformation modeling shows promise for providing more precise deformation estimation in applications that use computer-assisted image-guided intervention systems.
Highlights
Image-guided prostate interventions often require the registration of preoperative magnetic resonance (MR) images to real-time transrectal ultrasound (TRUS) images to provide high-quality guidance
Because collecting a sufficient number of representatives of the population as training data is essential for building an effective statistical model but collecting a large number of patient data is often difficult in clinical practice, biomechanical modeling shows promise as a way to generate sufficient data for statistical analysis
Impact of biomechanical parameter setting on deformation modeling
Summary
Image-guided prostate interventions often require the registration of preoperative magnetic resonance (MR) images to real-time transrectal ultrasound (TRUS) images to provide high-quality guidance. We propose a patient-specific deformation model equipped with personalized biomechanical parameters obtained from shear wave elastography to reliably predict the prostate deformation during image-guided interventions. The employment of the patient-specific biomechanical parameters obtained from elastography for deformation modeling shows promise for providing more precise deformation estimation in applications that use computer-assisted imageguided intervention systems. We can solve this problem either by accurately predicting the prostate deformation and precisely practicing the intervention in a simulation before the interventions or by fusing preoperative magnetic resonance (MR) images with the TRUS images to increase the accuracy of the interventions Both of these computer-assisted solutions need an accurate model to estimate the prostate deformation so that the surgeons can track the targets and perform the operation. We employed SWE to measure the in vivo biomechanical parameters of the prostate and assigned them to an FE model to form a patient-specific deformation model
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