Abstract

Trichothecenes are natural secondary metabolites causing economic losses and health hazard to human and farm animals which are produced by several species of Fusarium and some other genera on different agricultural commodities. Study on trichothecenes mycotoxicosis revealed morphological, biochemical, and histopathological changes. After intraperitoneal injection of the toxin in male mice with different concentration for 35 days shows marked increase in body weight, dyspanea, shivering, bristling up of hair, hair falling, anomalies of eyes, and irritation around neck, also abdominal hemorrhage and clot accumulation in abdomen. In addition to inclusion (retention) cyst forms on liver. The biochemical studies on liver function by measuring GPT and GOT enzymes level have been done. An increase level of these enzymes in treated animal in comparison with control animal which indicating abnormal function of liver observed. The histopathological study on sections from the liver of treated animal with trichothecenes revealed many alterations in liver which includes congestion, kupffer cells hyperplasia, dilated sinusoids and mononuclear cells infiltration around the portal area.

Highlights

  • Mycotoxins are important fungal secondary metabolites with low molecular weight; they are representing a potential threat to human and animal

  • Trichothecenes comes after aflatoxin in toxicity and it affects both man and animal.This mycotoxin affects cereal grains, farm animal which consume contaminated feed, affects man causing diseases, such as Alimentary Toxic Aleukia and Skeletal affliction (Kashin-Back disease)[3]

  • Materials and Methodes 1-Isolation and Identification of Fusarium oxysporum The fungi isolated according to [6] about 30 randomly selected corn seeds were surface sterilized seeds were cultured on Potato Dextrose Agar (PDA), 2 seeds for each plate incubated at 25oC for 7 days, the grown Fusarium (Which was morphologically identified) purified by new subculturing (each one in single plate of Potato Sucrose Agar (PSA)) this purified isolates were used for identification

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Summary

Introduction

Mycotoxins are important fungal secondary metabolites with low molecular weight; they are representing a potential threat to human and animal. GOT‫ و‬GPT ‫ اظھرت الدراسة الكيميائية الحيوية للكبد من قياس مستوى انزيمات‬. ‫ اظھرت العديد من التغيرات و التي تتضمن الاحتقان و زيادة غير طبيعية‬, ‫المختبرية المعاملة بسم الترايكوثيسين‬

Results
Conclusion

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