Abstract
Histological and immunohistochemical examinations were carried out on lymph nodes in 9 cases with Castleman's disease. In all cases, there were whorled follicle centers and proliferation of blood vessels. These findings were also considered to be important criteria for diagnosis of the plasma cell type of this disease. The whorled follicle centers often consisted of smaller concentrical structures and contained factor VIII-positive cells. In some cases, there were many small whorled structures surrounding postcapillary venules within the interfollicular areas of lymph nodes. These structures had factor VIII-positive granules indicating their endothelial origin. In 2 cases of the plasma cell type, monoclonal plasma cell proliferation (IgA, lambda and IgG, lambda, respectively) and cellular atypia were identified. These findings showed that extramedullary plasmacytoma could occur not only in the multicentric form, but also in the solitary form of Castleman's disease. In the lymph node of a case of the hyaline-vascular type, there were scattered tumour nodules consisting mainly of factor VIII-positive, atypical spindle cells suggesting associated Kaposi's sarcoma. It is conceivable that an abnormal immune state plays a role in pathogenesis of Castleman's disease.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Virchows Archiv. A, Pathological anatomy and histopathology
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
