Abstract
Aim. The aim of the study was to investigate the gender structure, peculiarities of fatigue syndrome and depressive disorders in patients with disseminated sclerosis (DS); to determine the cytokine status and neurotrophic mechanism, serotoninergic, semaphorin Sema4 (CD100) statuses of the above mentioned disease. Materials and methods. Patients with a reliable diagnosis of disseminated sclerosis were examined according to McDonald 2010 criteria with remittent type of disease course. Clinical method, psychometric testing, immune-enzyme analysis, immunological methods were used. Results. In process of disseminated sclerosis, patients' gender shifts to femininity. Fatigue and emotional disorders are inseparable symptoms of this disease. Neurochemistry of disseminated sclerosis is characterized by serotoninergic insufficiency and deficiency of neurotrophic mechanisms; inflammatory process does not stop in the phase of clinical remission, but semaphorin system is participating in formation of immunopathological reactions. Conclusions. Clinical and pathogenetic characteristics of disseminated sclerosis are supplemented by new data, which can be the targets of new therapeutic strategies.
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