Past, Present, and Future of Sodium Hypochlorite in Dermatology: A Scoping Review.

Wound Literature Review 2010

Objective: Scoping reviews use a systematic approach to synthesize a body of knowledge. The use of scoping review methodology is increasingly common. Despite recommendations to guide the conduct of scoping reviews, inconsistencies exist with regards to their methodology and reporting. In this case-study, we reflect on our experience using the PRISMA Extension for Scoping Reviews (PRISMAScR): Checklist and Explanation to improve reporting for a scoping review we initially conducted prior to the release of the PRISMA-ScR reporting guidelines. Study Design and Methods: We evaluated the scoping review against 22 criteria included in the PRISMA-ScR. For each criterion, we provided a rating representing the degree to which we felt the scoping review met the individual criterion in the PRISMAScR. We also provided comments to substantiate our ratings, along with recommended revisions for the scoping review and considerations for future scoping reviews. Results: We identified a number of strengths in the initial reporting of our scoping review , as well as opportunities for improvement. The most substantial areas for zmprovement included the protocol registration, data items and data charting process. Based on our evaluation, we made revisions to the scoping review manuscript to improve our reporting. Conclusion: Our evaluation helps to highlight the value of using reporting guidelines to improve reporting of scoping reviews, while also exposing several challenges. In future, we recommend consulting the guidelines during the initial preparation of the scoping review manuscript rather than retrospectively. What is already known about the topic? The use of scoping review methodology is becoming increasingly common. While recommendations to guide the conduct of scoping reviews have been published, inconsistencies exist in both scoping review methodology and reporting. What this paper adds: Despite some challenges, we found the PRISMAScR to be an effective tool to guide a structured reflection on our scoping review reporting. We encourage authors completing scoping reviews to make use of the PRISMA-ScR to guide their own scoping review reporting.

With humor and determination, a 9/11 survivor heals.

The selection of an appropriate chemical solution in wound care reduces the severity of wounds and accelerates the healing process. Povidone-iodine (PV-I), a chemical solution popularly known as an antiseptic, is frequently used in studies of wound care to prevent wound infection and accelerate woud the process of wound healing. To identify the latest evidence on the benefits of PV-I in wound infection prevention and healing in all areas. This review is a scoping review by Arskey and O'Malley and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews (PRISMA-ScR) is used for reporting. The literature search used databases including PubMed, CINAHL, and search engines such as Scopus. This study was conducted using thematic analysis. This review yielded 19 out of 2109 studies that were identified in the initial search. Four outcomes comprised 20 sub-outcomes have been identified. Although strong evidence is lacking, PV-I in the form of foam is effective in improving wound healing, shortening healing time, and producing fewer adverse events than hydrocelluers. Moreover, saline and PV-I are effective as skin disinfectants when compared to saline alone in reducing surgical site infection (SSI), and they are also more effective than hypochlorous acid in improving wound healing. Nevertheless, there was no difference between PV-I and hypochlorous acid in the prevention of SSI and bacterial growth. In terms of healing time, silver foam and hyaluronic acid were more favorable than PV-I. Moreover, the use of chlorhexidine to improve SSI and silver dressing to improve hospital stay is more favorable than that of PV-I. There is limited evidence regarding the effectiveness of wound care outcomes, and the efficacy of PV-I as a surface disinfectant for wound infectionprevention remains controversial. Consequently, PV-I is not highly recommended for wound care, and further investigation into the effectiveness of PV-I as a surface disinfectant is required for various types of surgeries.

This report characterizes an aqueous isolate (SBD.4) of one of the most broadly used Chinese medicinal herbs, Angelica sinensis, from the perspective of its application in skin and wound care. SBD.4 has been chemically defined and was found to increase the strength of healed wounds in retired breeder (older) rats. Furthermore, the mechanism of action of this Angelica sinensis isolate was tested in the zebrafish angiogenesis model, and in human skin substitutes by DNA microarray, revealing a bioactivity profile consistent with skin repair and regeneration. When combined with several types of wound dressings, SBD.4 increased type I collagen production in human dermal fibroblasts, and when formulated in nanosilver hydrocolloid dressing, it was found effective in chronic ulcer management in humans, demonstrating that botanical high-tech wound dressings can be successfully developed to improve the treatment of chronic lesions in humans.

BackgroundA rapidly aging population, a shifting disease burden and the ongoing threat of infectious disease outbreaks pose major concerns for Vietnam’s health care system. Health disparities are evident in many parts of the country, especially in rural areas, and the population faces inequitable access to patient-centered health care. Vietnam must therefore explore and implement advanced solutions to the provision of patient-centered care, with a view to reducing pressures on the health care system simultaneously. The use of digital health technologies (DHTs) may be one of these solutions.ObjectiveThis study aimed to identify the application of DHTs to support the provision of patient-centered care in low- and middle-income countries in the Asia-Pacific region (APR) and to draw lessons for Vietnam.MethodsA scoping review was undertaken. Systematic searches of 7 databases were conducted in January 2022 to identify publications on DHTs and patient-centered care in the APR. Thematic analysis was conducted, and DHTs were classified using the National Institute for Health and Care Excellence evidence standards framework for DHTs (tiers A, B, and C). Reporting was in line with the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews) guidelines.ResultsOf the 264 publications identified, 45 (17%) met the inclusion criteria. The majority of the DHTs were classified as tier C (15/33, 45%), followed by tier B (14/33, 42%) and tier A (4/33, 12%). At an individual level, DHTs increased accessibility of health care and health-related information, supported individuals in self-management, and led to improvements in clinical and quality-of-life outcomes. At a systems level, DHTs supported patient-centered outcomes by increasing efficiency, reducing strain on health care resources, and supporting patient-centered clinical practice. The most frequently reported enablers for the use of DHTs for patient-centered care included alignment of DHTs with users’ individual needs, ease of use, availability of direct support from health care professionals, provision of technical support as well as user education and training, appropriate governance of privacy and security, and cross-sectorial collaboration. Common barriers included low user literacy and digital literacy, limited user access to DHT infrastructure, and a lack of policies and protocols to guide the implementation and use of DHTs.ConclusionsThe use of DHTs is a viable option to increase equitable access to quality, patient-centered care across Vietnam and simultaneously reduce pressures on the health care system. Vietnam can take advantage of the lessons learned by other low- and middle-income countries in the APR when developing a national road map to digital health transformation. Recommendations that Vietnamese policy makers may consider include emphasizing stakeholder engagement, strengthening digital literacy, supporting the improvement of DHT infrastructure, increasing cross-sectorial collaboration, strengthening governance of cybersecurity, and leading the way in DHT uptake.

Aerosolized sodium hypochlorite inhibits viability and allergenicity of mold on building materials

Scoping reviews, a type of knowledge synthesis, follow a systematic approach to map evidence on a topic and identify main concepts, theories, sources, and knowledge gaps. Although more scoping reviews are being done, their methodological and reporting quality need improvement. This document presents the PRISMA-ScR (Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews) checklist and explanation. The checklist was developed by a 24-member expert panel and 2 research leads following published guidance from the EQUATOR (Enhancing the QUAlity and Transparency Of health Research) Network. The final checklist contains 20 essential reporting items and 2 optional items. The authors provide a rationale and an example of good reporting for each item. The intent of the PRISMA-ScR is to help readers (including researchers, publishers, commissioners, policymakers, health care providers, guideline developers, and patients or consumers) develop a greater understanding of relevant terminology, core concepts, and key items to report for scoping reviews.

ObjectivesThe hospital-at-home (HaH) model has gained traction as a viable alternative to traditional inpatient care, allowing patients to receive care in their own homes. Despite its growing popularity, there is a lack of comprehensive research addressing effectiveness, safety and factors critical to the successful implementation of HaH programmes. We conducted a scoping review to comprehensively map and summarise the evidence on both admission avoidance and early-supported discharge up until now.DesignA scoping review of randomised controlled trials (RCTs), conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis: extension for Scoping Reviews (PRISMA-ScR) guidelines.Data sourcesOvid MEDLINE, Embase, CINAHL and Web of Science were systematically searched up to July 2024Eligibility criteria for selecting studiesWe included English-language RCTs published from 2005 onwards, involving adults (≥18 years) receiving acute care at home who would otherwise require hospital admission. Eligible studies evaluated admission avoidance or early supported discharge within HaH settings for acutely ill patients. Studies focusing on outpatient care, non-acute conditions or interventions not aligning with the widely accepted HaH definition were excluded. COVID-19-related studies were also excluded to avoid context-specific bias.Data extraction and synthesisTwo reviewers independently extracted data on study characteristics, interventions and outcomes including mortality, length of stay, escalation rates, costs and patient and caregiver satisfaction. Implementation facilitators and barriers were also collected. Discrepancies were resolved by a third reviewer. Results were synthesised descriptively in accordance with PRISMA-ScR guidelines.ResultsNine RCTs were identified. The review shows that the HaH model is at least as safe as usual care, with lower or comparable mortality rates. Length of stay varied, with some studies reporting longer stays in the HaH group due to cautious clinical practices. Cost analyses often indicate lower healthcare costs with staffing as the largest expense. Patient and caregiver satisfaction was high, but essential implementation factors were not clearly addressed.ConclusionThe HaH model represents a promising alternative to acute inpatient care for suitable patients. Future research should focus on conducting larger RCTs, expanding the range of conditions suitable for HaH. Despite favourable clinical outcomes, substantial implementation barriers remain underexplored in current RCTs. This underscores the need to identify strategies for successful implementation, including the integration of technological advancements and qualitative insights into patient and caregiver experiences.

PurposeAnkle fractures are increasingly common in the elderly and present unique challenges due to osteoporosis, comorbidities, and frailty. Management remains controversial, with surgical fixation generally favored, though the optimal approach is debated. This scoping review aimed to map current evidence on the management of ankle fractures in patients aged 65 and over, highlighting treatment strategies, outcomes, and gaps in knowledge.MethodsA scoping review was conducted in accordance with The Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews (PRISMA-ScR). We systematically searched PubMed, Embase, and Cochrane Library from 2010 to 2024. Eligible studies reporting treatment outcomes in elderly patients were included. Data were charted and summarized narratively; pooled descriptive analyses were presented to illustrate trends, consistent with PRISMA-ScR methodology.ResultsA total of 4783 articles were identified, of which 32 met the inclusion criteria. Of the 32 studies analyzed, 24 were conducted in Europe, 5 in the United States, and 1 each in China, Korea, and New Zealand. Study designs comprised 27 retrospective observational studies, 3 randomized controlled trials, one prospective case series and one ambispective cohort study. Open reduction and internal fixation remain the standard surgical method, while alternatives such as tibiotalocalcaneal nailing and fibular intramedullary nailing are increasingly reported. Overall functional recovery was satisfactory, but outcomes varied by comorbidity burden, fracture pattern, and rehabilitation strategy. Complication rates were substantial, with wound problems, fixation failure, and infections most frequent. Mortality ranged from 10 to 27%, with higher rates in nonoperative and frail populations. Evidence on weight-bearing protocols and long-term outcomes remains inconsistent.ConclusionsCurrent evidence supports surgery as the preferred option for most elderly ankle fractures, though individualized, multidisciplinary care is essential. Research gaps include standardized fixation protocols, comorbidity-adjusted pathways, and long-term functional outcomes. High-quality prospective studies are needed to refine clinical recommendations.

This scoping review aimed to map global evidence on upstream interventions which promote oral health and reduce socioeconomic inequalities in oral health. A review was undertaken in accordance with the Joanna Briggs Institute (JBI) methodology for scoping reviews and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews (PRISMA-ScR) checklist. A multistranded comprehensive search strategy was employed to identify relevant studies. Article texts were retrieved and assessed for eligibility against the inclusion criteria. Key findings were extracted and summarised. A total of 99 articles (74 empirical studies and 25 systematic, scoping and umbrella reviews) were included in the scoping review. The review findings revealed a limited number of upstream interventions specifically focused on promoting oral health and reducing oral health inequalities. Legislative and regulatory measures (e.g., advertising controls), fiscal measures (e.g., sugar-sweetened beverage taxation) and specific oral health interventions (e.g., water fluoridation) have shown a positive impact on promoting oral health. In addition, fiscal measures, food subsidies targeted at low-income groups and improvements to housing/work environments have proven effective in reducing socioeconomic inequalities in general health outcomes. Despite a very detailed and thorough search of the global literature, this scoping review identified a limited number of upstream interventions that specifically focused on improving oral health, and an even smaller number of upstream interventions that tackled oral health inequalities. However, the review did identify three levels of upstream intervention including: policies tackling the broader socio-political determinants of health; policies combating non-communicable diseases (NCDs) linked to oral health; and some specific interventions (e.g., water fluoridation) focusing on oral health. The upstream approach to prevention remains highly relevant to public health policy and provides a guiding principle for future strategic action to promote oral health and tackle oral health inequalities.

This review concerns five species of trees and palm trees that occur as dominant plants in different rainforest areas of the Amazon region. Due to their abundance, these species can be exploited as sustainable sources of botanical materials and include Carapa guianensis Aubl., family Meliaceae; Eperua falcata Aubl., family Fabaceae; Quassia amara L., family Simaroubaceae; and Attalea speciosa Mart. and Oenocarpus bataua Mart., family Arecaceae. For each species, the general features, major constituents, overall medicinal properties, detailed dermatological and skin care applications, and possible harmful effects have been considered. The major products include seed oils from A. speciosa and C. guianensis, fruit oil from O. bataua, and active compounds such as limonoids from C. guianensis, flavonoids from E. falcata, and quassinoids from Q. amara. The dermatologic and cosmetic applications of these plants are growing rapidly but are still widely based on empiric knowledge. Applications include skin rehydration and soothing; anti-inflammatory, antiage, and antiparasite effects; hair care; burn and wound healing; and the amelioration of rosacea and psoriasis conditions. Despite a limited knowledge about their constituents and properties, these species appear as promising sources of bioactive compounds for skin care and health applications. An improvement of knowledge about their properties will provide added value to the exploitation of these forest resources.

Scoping reviews are an increasingly popular methodological approach to collate evidence and synthesise knowledge in many fields including occupational therapy. However, many are published with potential methodological weaknesses. To address this issue, nine methodological recommendations that authors could adopt to improve the quality and rigour of published scoping reviews are proposed based on the authors' opinions and the published evidence. It is suggested that when authors are completing a scoping review, they can consider completing one or more of the following methodological guidelines: (1) refer to the Levac et al.'s (2010) scoping review recommendations, the JBI Scoping Review Protocol, and the PRISMA Extension for Scoping Reviews (PRISMA-ScR) Checklist as methodological guides; (2) include grey literature as a standard component search strategy approach; (3) include thesis and dissertations as recognised sources of evidence; (4) apply a recognised research methodology critical appraisal/quality assessment tools and scales to evidence selected for inclusion in scoping reviews; (5) assign a level of evidence (LoE) framework to the selected evidence; (6) apply a recognised qualitative knowledge syntheses approach to the data extracted; (7) report the steps taken to ensure the trustworthiness of the qualitative knowledge synthesis approach used; (8) include consumer, stakeholder and community consultation; and (9) apply a scoping review-specific critical appraisal/quality assessment tool as a quality assurance activity. The authors are not proposing that the nine recommendations are mandatory, but instead they are methodological guidelines that scoping review authors can incorporate if they choose. Consumers and community members were not involved in the writing of the manuscript. Adopting the suggested methodological recommendations as a regular part of completing occupational therapy-related scoping reviews will increase their quality, precision, and rigour.

This scoping review aims to map the evidence on circus activities described and/or evaluated as a health intervention for children, youths, and adolescents. Increased understanding of how these interventions work, and gaps identified, will allow researchers and practitioners to advance the science behind these approaches. Circus activities are proposed in the literature as a health intervention, due to their variety, non-competitive nature, and potential to develop fundamental physical and social skills. For the purposes of this review, circus activities as a health intervention are defined as aerial, acrobatic, equilibristic, and manipulation skills taught to participants to maintain, improve, or modify health, functioning, or health conditions. English-language evidence will be considered where circus activities as a health intervention are described and/or evaluated for participants up to 24 years of age, or who are defined as children, youths, or adolescents. Literature will be excluded where the focus of the intervention is clowning, magic, or drama games, or where circus activities are not the therapeutic part of the activity. MEDLINE (Ovid), CINAHL Complete (EBSCO), Scopus (Elsevier), PsycINFO (Ovid), ProQuest Dissertations and Theses Global, and Google Scholar will be searched for peer-reviewed and gray literature. No restriction on dates, type, methodology, or setting will be imposed, but limits will include "human" and "English language." Screening and data extraction will be performed by two independent reviewers. Reference lists of included sources will be screened. Results will be presented in diagrammatic or tabular format, alongside a narrative description, under headings aligning with the research sub-questions.

Background:Coleus amboinicus (Lour.) (syn Plectranthus amboinicus) from the Lamiaceae family-a large family of aromatic herbs with many medicinally important species-is a frequently cited species within the Plectranthus genus, renowned for its traditional uses, phytochemical composition, biological activities, and applications in skin care. Methods: A systematic review was conducted following PRISMA guidelines to provide an in-depth understanding of P. amboinicus' phytochemical composition and biological activity, particularly in dermatological contexts, underscoring its significance in traditional medicine and modern phytochemical research. Results: P. amboinicus extracts and essential oils exhibit significant antimicrobial activity against both Gram-positive and Gram-negative bacteria, and notable antifungal properties, particularly against dermatophytes. Additionally, the species demonstrates remarkable mosquito repellent and anti-parasitic effects, comparable to DEET, and potent anti-inflammatory properties by inhibiting pro-inflammatory cytokines. The plant's rich polyphenolic content contributes to its significant antioxidant properties, preventing conditions like hyperpigmentation and premature aging. P. amboinicus also exhibits cytotoxic activity against various cancer cell lines and promotes wound healing through its analgesic, anti-inflammatory, and antioxidant abilities. Conclusions: This comprehensive exploration of P. amboinicus validates its diverse therapeutic potential across infectious diseases, oncology, and wound care. Further research and clinical trials are warranted to fully elucidate its mechanisms of action and optimize its therapeutic applications, paving the way for its integration into mainstream medical practices.