Abstract
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Highlights
The effect of hyperimmune serum against B. bronchiseptica was investigated in relation to various concentrations of challenge doses of B. bronchiseptica in three groups of gnotobiotic piglets kept in incubators throughout the experiment
Of 7 control piglets i1ntothi2s),gwrohuepr,ea6ssahnowtheed turbinate atrophy varying from 6 experimental piglets passively slight to moderate (grade immunized with the hyperimmune serum exhibited no gross changes and had, for the most part, lower counts of organisms in the nasal cavities than the controls (Table 1)
Our experiments with administration of hyperimmune sera were guided by the observations that colostral antibodies may protect piglets from the development of atrophic changes fairly well provided that the infecting doses of B. bronchiseptica are not too high (Koshimizu et al.1973)
Summary
Kuksa: Passive and Active Protection Against the Development of Pathological Changes in Piglets Infected with Bordetella bronchiseptica. Active and passive immunization of piglets against Bordetella bronchiseptica restricted the development of gross changes in the nasal turbinates and lung after intranasal or contact infection. After double vaccination of 4 conventional piglets into the nasal submucosa, slight turbinate atrophy was found in 1 experimental animal as against 2 out of 4 controls. After double subcutaneous vaccination of 6 conventional piglets, all experimental animals had normal turbinates where as 3 of 6 -controls showed turbinate atrophy. The numbers of B. bronchiseptica in the turbinate mucosa and lung were generally higher in the controls than in actively or passively immunized piglets. 1967; Harris and Switzer 1968; Shimizu 1971; Kemeny 1972; Logomarsino et at 1974; GoiS et a!. Mild forms of turbinate atrophy after experimental infection with B. bronchiseptica alone have been reported by a number of investigators (Ross et a!. 1967; Harris and Switzer 1968; Shimizu 1971; Kemeny 1972; Logomarsino et at 1974; GoiS et a!. 1974; Brassinne et a!. 1976; Edington et a!. 1976; Tornoe and Nielsen 1976)
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