Abstract

The salivary glands have a high rate of metabolism and blood flow and indirectly depend on thyroid function. In the present study the influence of prostaglandin (PG) on salivary secretion in hyperthyroid rats was investigated. Study Design: Male Wistar rats, initial weight of 220 g, were distributed into two groups, euthyroid (EU) or hyperthyroid (HYPER), and treated with thyroxine (300μg/Kg; s.c; 7 days). EU and HYPER rats received meloxicam (MLX; 0.5 mg/kg; i.p.), a preferential cyclooxygenase-2 (COX-2) inhibitor, 30 minutes before salivary stimulation with pilocarpine (5 mg/kg; i.p.). Saliva was collected over a 15-minute period (μL/min/100 g body wt.) from the time of the first drop of saliva. Results: Hyperthyroidism increased salivary flow rate. COX-2 did not alter salivary flow in either group of rats (Mann-Whitney test; p < 0.05). Conclusion: COX-2 inhibition and, consequently, the synthesis of PGs by the injection of MLX, a non-steroidal anti-inflammatory drug, did not modulate the salivary secretion of HYPER rats.

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