Abstract
Partially Hydrolyzed Formulas: Do They Play Any Role in the Prevention of Atopic Dermatitis?
Highlights
Atopic Dermatitis (AD) is a chronic, recurrent, inflammatory skin disease with an immune mechanism
In order to try to contain this trend, several strategies have been designed in the field of nutrition that have gone from focusing on avoiding exposure to the allergens most commonly involved in allergic diseases through diets in the pregnant and nursing mother, the use of highly hydrolyzed formulas in the first months of life and the delay in the introduction of some foods to a more active form of prevention based on immunomodulation and in trying to promote the induction of tolerance through eating patterns in the first months of life, a key period in the development of tolerance phenomena
Unlike extended or high-grade hydrolysates, partial hydrolysates are contraindicated in children with a diagnosis of cow’s milk proteins allergy since they contain peptides whose molecular weight ranges from 4,000-10,0000 daltons on average to a high likelihood may trigger an allergic reaction in sensitized children [8]
Summary
Atopic Dermatitis (AD) is a chronic, recurrent, inflammatory skin disease with an immune mechanism. In order to try to contain this trend, several strategies have been designed in the field of nutrition that have gone from focusing on avoiding exposure to the allergens most commonly involved in allergic diseases through diets in the pregnant and nursing mother, the use of highly hydrolyzed formulas in the first months of life and the delay in the introduction of some foods to a more active form of prevention based on immunomodulation and in trying to promote the induction of tolerance through eating patterns in the first months of life, a key period in the development of tolerance phenomena This is a strategy that is considered today more attractive than the exclusion diet because it is relatively simple, it is not expensive and the risk of adverse consequences from the nutritional point of view is low. This article focuses exclusively on the role of a Partially Hydrolyzed serum Formula (PHFs) in the first months of life, as a preventive measure for the subsequent development of a DA, without considering the possible effect that the other dietary measures proposed may have on the prophylaxis of allergic diseases in general
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