Abstract
One Brazilian strain of Aujeszky’s disease virus isolated from a piglet in which the disease had not been observed was studied as for its virulence in pigs. The genome of the virus was molecularly analysed as for their restriction endonuclease cleavage pattern. Fifty-day-old non-immune weanlings exposed to this strain showed no disease although the virus was present in their oropharyngeal area for at least three days. All animals developed moderate titers of neutralizing antibody. Based on number of bands and migration rate of restriction fragments the isolate was classified into Herrmann’s type I group. Latent infection was detected in all pigs by PCR. Some variations were detected in the cleavage pattern of the strain ASB Piau when compared to LA031 virulent Brazilian strain, that could be related to differences in the virulence.
Highlights
Aujeszky’s disease (AD) is caused by swine herpesvirus 1 (SHV-1) which belongs to the subfamily Alphaherpesvirinae
Recovery from SHV-1 infection often results in the establishment of a carrier state in the trigeminal nerve ganglia, as well as development of humoral and cellular immunity (Carneiro & Cardim, 1947; Gustafson, 1986)
No strong signs of AD were observed in the pigs exposed to ASB Piau strain except a temperature response, observed 24 to 48 hours after infection
Summary
Aujeszky’s disease (AD) is caused by swine herpesvirus 1 (SHV-1) which belongs to the subfamily Alphaherpesvirinae. One tissue culture cloned SHV-1 strain which was isolated from a piglet from a Brazilian Piau herd, in which clinical signs of AD had not been observed, was analyzed. The ASB Piau strain of SHV-1 was isolated from a piglet tonsil from a herd in which AD had not been clinically observed
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