Abstract
Membrane-bound Klotho is the coreceptor for fibroblast growth factor 23 (FGF23) that increases its affinity for FGF receptors (FGFRs).[1][1] Binding of FGF23 to FGFR-Klotho complexes in the kidney stimulates phosphaturia and inhibits production of 1,25-dihydroxyvitamin D.[2][2] In the parathyroid
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