Abstract
It has been previously observed that perfusion of the thyroid-parathyroid gland complex in the dog with high calcium blood results in liberation of a hypocalcemic factor, calcitonin. In sheep, the superior parathyroid gland is separated by 2–3 cm from the thyroid and has a distinct blood supply, so that it can be perfused independently. Perfusion of this gland with high calcium blood (10.8–12.8 mg/100 ml) in 6 sheep, 3 of which had been thyroidectomized immediately prior to perfusion, resulted in a prompt fall in systemic plasma calcium, the change in 30 min being -0.530 ±0.074 mg/100 ml. Subsequently, in 5 adult sheep and 5 lambs, the thyroid was first perfused with high calcium blood for 1 hr, and then the superior parathyroid. Perfusion of the thyroid had no significant effect on systemic plasma calcium, but perfusion of the superior parathyroid resulted in a significant fall at 10 min and a change of -0.706 ±0.088 mg/100 ml by 30 min. The drop 30 min following parathyroidectomy was small and not stati...
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