Abstract
Abstract In addition to stimulating ion transport and respiration, it is now established that the parathyroid hormone induces rapid and extensive mitochondrial swelling. The swelling process takes place in the absence of Mg++ in a medium composed of sucrose, substrate, and tris(hydroxymethyl)aminomethane. If Mg++ is present, the swelling change is greatly minimized. The swelling is accompanied by a simultaneous increase in pyridine nucleotide oxidation and respiration, and is neither dependent upon nor enhanced by K+ or Na+. Inorganic phosphate, acetate, and, to a lesser extent, arsenate stimulate the rapidity and extent of the parathyroid hormone-induced swelling. The results suggest that parathyroid hormone-induced swelling is closely related to the ion transport and respiration responses.
Highlights
In addition to stimulating ion transport and respiration, it is established that the parathyroid hormone induces rapid and extensive mitochondrial swelling
The swelling process takes place in the absence of Mg++ in a medium composed of sucrose, substrate, and tris(hydroxymethyl)aminomethane
The results suggest that parathyroid hormone-induced swelling is closely related to the ion transport and respiration responses
Summary
In addition to stimulating ion transport and respiration, it is established that the parathyroid hormone induces rapid and extensive mitochondrial swelling. Recent studies on the mechanism of action of parathyroid hormone have shown that this peptide, too, is capable of inducing ion transport in isolated mitochondria [7,8,9] This hormone has been shown to stimulate nonphosphorylative oxidation under a variety of conditions [10, 11] and its site of action is well defined [7, 10,11,12]. This study was made feasible through the availability of a device for the simultaneous measurement of swelling (90’ light scattering), respiration, and pyridine nucleotide oxidation [13] These experiments form the basis of the present report
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
