Abstract
Neuromyelitis optica spectrum disorder (NMOSD) is a relapsing demyelinating and inflammatory disease of the central nervous system, mediated by aquaporin-4 (AQP4)-immunoglobulin G (IgG) autoimmunity. Although NMOSD is most commonly an idiopathic autoimmune condition, it may also occur as a paraneoplastic syndrome in rare instances. Hereby, we report a rare case of a 61-year-old lady with paraneoplastic AQP4-IgG NMOSD associated with adenocarcinoma of sigmoid colon.
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