Abstract
Background: Paraneoplastic brainstem encephalitis (PBE) is a rare syndrome and has been described in patients with lung and breast cancer. Several anti-neuronal nuclear antibodies are associated with PBE. Case Report: We experienced a case of a 79-year-old man who suddenly developed memory loss, diplopia and cerebellar ataxia. Brain magnetic resonance imaging (MRI) revealed high signal intensity in midbrain, pons and middle cerebellar peduncle on T2-weighted and fluid attenuation inversion recovery (FLAIR) images. Chest computed tomography (CT) revealed a lung mass ; and serum tests were posi tive for anti-Hu antibody. The patient was unresponsive to all treatments including immunotherapy. Conclusion: We reported a patient with acute-onset of PBE with anti-Hu antibody. Anti-Hu antibody associated brainstem encephalitis is usually non-responsive to immunotherapy. Earlier diagnosis and treatment are a challenge for improving the prognosis of paraneoplastic brainstem encephalitis. J Neurocrit Care 2015;8(2):126-129
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
