Abstract
Arachidonic acid at concentrations from 0.2 to 2.0 × 10− 6M induces the secretion of lysosomal enzymes from cytochalasin B-treated rabbit neutrophils. These concentrations of arachidonic acid are metabolized primarily to hydroxyeicosatetraenic acids rather than to cyclooxygenase products. A good correlation is observed between the extent of arachidonic acid metabolism and the secretion of lysosomal enzymes. Nordihydroguaiaretic acid (1−10μM) inhibits both lysosomal enzyme secretion and the production of lipoxygenase products by neutrophils.
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