Abstract
AbstractThe classical concept that all complex life evolved from a simple bacterium-like life form has been questioned by comparative genomics and proteomics. Several discoveries, including the occurrence of entirely new genes in unexpected life forms without any precursors, and the random mosaic distribution of genes across organisms in higher taxa undermine the principal assertions of this theory. We present a new model of the pre-biotic parallel evolution of eukaryotic genomes starting with the structurally complex split genes, which are far more probable of supporting biological information and of occurring in random DNA sequences than contiguous genes. By comparing the mosaic patterns of simulated genomes and extant genomes, we show that genomes arising from simulated assembly of random split genes form the same gene distribution patterns observed in extant eukaryotes. This parallel genome origin model eliminates the post-genomic and classical conundrums faced by the linear branching evolution model.
Highlights
The currently accepted explanation for the origin of life may appear solid in its foundation
Genes similar to the set of “root-stock genes” in the earliest life form should occur in all life forms in the view of linear branching evolution (LBE), whereas what is observed in nature is a mosaic gene distribution (Figure 1A)
We have proposed the random sequence origin of split genes (ROSG)/parallel genome assembly (PGA) model that provides consistent non-teleological answers to the questions posed by emerging genomic data
Summary
The currently accepted explanation for the origin of life may appear solid in its foundation. The genome of the first life form appears to be highly complex and eukaryotic, containing genes encoding advanced proteins [31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47]. In contrast to the simple genes and primitive spliceosomes projected by LBE model, it has been shown that the first eukaryote contained highly complex, intron-rich split genes [24,25, 28, 75,76,77] and an advanced spliceosome [48,49,50,51] as those present in higher eukaryotes. Recent findings indicate that the first life form itself may have been eukaryotic containing complex split genes and an advanced spliceosome for splicing them
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