Abstract
Abstract A major obstacle to winning the war on cancer is a lack of understanding of how cancer develops. The dominant theory for the last 50 years has been the somatic mutation theory (SMT), which says that cancer arises directly from a sequence of genetic changes on a cell that leads to its proliferation. The alternative tissue organization field theory (TOFT) says that cancers arise from a disruption of cell communication needed to maintain normal tissue architecture. A historical background places these theories into perspective. Various experimental results are paradoxical under SMT, but readily explained under TOFT, suggesting paradigm instability. These paradoxical results offer new opportunities for cancer research.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
