Abstract
Paradox of Protection: Preferential Recognition of CD4-induced Epitopes by Anti-HIV-1 ADCC Antibodies
Highlights
Utilizing this technology, Williams et al identified three antibodydependent cellular cytotoxicity (ADCC) antibodies from an HIV-1 subtype A-infected donor
Both Vpu and Nef downregulate cell surface CD4 and prevent Env from entering the CD4-bound conformation prominently targeted by ADCC antibodies (Veillette et al, 2014, Veillette et al, 2015)
The Vpu and Nef-mediated down regulation of CD4 at first blush appears paradoxical to the notion that ADCC antibodies targeting the CD4
Summary
Williams et al identified three ADCC antibodies from an HIV-1 subtype A-infected donor. Much evidence points towards a role for Vpu and Nef in the evasion of ADCC responses by HIV-1-infected cells Both Vpu and Nef downregulate cell surface CD4 and prevent Env from entering the CD4-bound conformation prominently targeted by ADCC antibodies (Veillette et al, 2014, Veillette et al, 2015).
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