Abstract
No abstract.
Highlights
It is, usually preferred to use biologically effective (delivered, cell-associated or intracellular) doses compared to nominal dose or exposure
Nanotoxicology came to light in the years 2000, and rapidly became The Eldorado in toxicology, attracting many investigators, notably because significant public funding was available to address the growing health concerns posed by nanomaterials (NM) and their technological applications
Another source of debate is related to the definition and expression of the dose in nanotoxicology
Summary
It is, usually preferred to use biologically effective (delivered, cell-associated or intracellular) doses compared to nominal dose or exposure. Notably in nanotoxicology, we are dealing with solid materials that may have different modes of interaction with the cells, and defining the biologically effective dose is not a trivial issue (Figure 1).
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