Abstract
Pancreatic mesenchymal stromal cells: Characteristics and possible origin
Highlights
Mesenchymal stromal cells (MSCs) are heterogeneous population of cells that were primarily isolated from the bone marrow [1]
MSC-like cells have been isolated from other tissues like the human placenta [2], peripheral blood [3], umbilical cord [4], adipose tissue [5], endometrium [6] and pancreas [7,8]
Mesenchymal cells derived from the dedifferentiated exocrine cells were characterized as MSCs, as they expressed markers of MSCs and showed the ability to differentiate into cells of mesodermal lineages
Summary
Mesenchymal stromal cells (MSCs) are heterogeneous population of cells that were primarily isolated from the bone marrow [1]. MSCs isolated from pancreatic duct tissue cultures expressed pancreatic endocrine progenitor markers such as PAX4 and Ngn3, when induced to differentiate into cells of endocrine lineage [7]. Epithelial to mesenchymal transition process(EMT) was suggested as a possible mechanism of generation of mesenchymal stem cells from cultured exocrine acinar and duct cells [22,24,29,].
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