Abstract
BackgroundThe probable mechanism of an earlier reported capacity of palm oil extracts to confer protection against high dose cadmium poisoning in rats was reported in this study. Similar experimental design earlier reported by us was retained. Rats therefore were sacrificed at intervals of twelve; twenty four and forty eight hours post CdCl2 insult.ResultsOxidative stress and antioxidant status (malondialdehyde, superoxide dismutase, catalase and glutathione) were assessed in tissues (liver, kidney, heart, brain, muscle) and serum. Oxidative stress indicators showed a significantly (p < 0.05) increased lipid peroxidation and alterations in antioxidant defence systems occasioned by drop in catalase and superoxide dismutase enzymes (serum, liver, heart, brain and kidneys) of the rats. Also observed were significant (p < 0.05) reduction in the non-enzymatic antioxidant reduced glutathione over time. Pre-administration of rats with the crude palm oil and its extracts modulated cadmium mediated depletion of the antioxidant capacities of rats acutely exposed to cadmium and rising lipid peroxidation profile.ConclusionsRegulation of stress and antioxidant response was the underlying mechanism by which the extracts conferred protection against high dose cadmium insult thus suggesting its potential as a viable therapeutic target against its deleterious effects.Graphical
Highlights
The probable mechanism of an earlier reported capacity of palm oil extracts to confer protection against high dose cadmium poisoning in rats was reported in this study
1. 28 days administration of Palm oil and its fractions contributed in boosting antioxidant defence system by increasing activities of superoxide dismutase (SOD), Catalase (CAT) and levels of reduced glutathione (GSH) in serum rat tissues
Oxidative radicals contributes to inhibition and depletion of antioxidants (CAT, SOD and Reduced Glutathione (GSH))
Summary
The probable mechanism of an earlier reported capacity of palm oil extracts to confer protection against high dose cadmium poisoning in rats was reported in this study. Cadmium poses risk at the slightest level of exposure to animals and plants. This is because the body does not have much capacity to degrade it to less harmful chemical forms. It is poorly excreted and is bio-accumulated (Dong et al 2019). Its symptoms usually manifests within 24 h affecting cardiovascular functions. This leads to shortness of breath, general weakness and fever. The use of natural products for treatments of various forms of poisoning proves to exert negligible side effects and is not financially debilitating (Oyem et al 2021; Orororo et al 2018a, b, c, d, e; Okpoghono et al 2018; Atagana and Asagba 2015)
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