Abstract
AbstractCyclic nitrones are an important class of functional molecules in organic synthesis and various other fields. However, their syntheses typically rely on stoichiometric transformations; catalytic versions are rare and highly substrate‐specific. Herein we defined the scope and limitation of PdII‐catalyzed Cope‐type hydroaminations of several types of ω‐alkenyl oximes en route to various 5‐ and 6‐membered cyclic nitrones. The study revealed the electronic requirement of the key migratory insertion step and paves the way for further developments of enantioselective processes and three‐component versions with an external trapping agent.
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