Abstract
A palladium-catalyzed double carbonylation of propargyl diols with primary amines has been developed for the expedite construction of 4-oxo-4-(aryl/alkylamino)butanoic acid scaffolds. With benzene-1,3,5-triyl triformate (TFBen) as the CO surrogate, the reaction with aromatic and aliphatic primary amines proceeded well to give a variety of functionalized acids in high yields.
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