Abstract

EEG biomarkers of early auditory information processing, such as mismatch negativity (MMN) and P3a, have been instrumental in understanding cognitive deficits in schizophrenia (SZ). However the impact of medication factors, specifically anticholinergic medication burden, have not been assessed. Multiple reports have described that anticholinergic medication burden (ACB) is substantial in SZ, stems from multiple different classes of medications, and impairs cognitive functioning across multiple domains. We therefore investigated the impact of anticholinergic medication burden on MMN/P3a in a large cohort of SZ outpatients.

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