Abstract
Breast cancer is the most common cancer among women in the US, with the skeleton as its most common metastasis site. These lesions weaken bones sufficiently such that fractures occur when subjected to forces encountered during daily activities. With treatment, breast cancer patients with skeletal metastasis continue to lead productive lives, yet current clinical and radiographic guidelines to estimate fracture risk associated with metastatic lesions are inaccurate. Prevention of metastatic fractures depends on objective criteria that reliably predict the maximum load bearing capacity of affected bone and be used to monitor the response of lesions to treatment.
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