Abstract
Modelling of EEG during mismatch negativity, 40 Hz auditory steady state response and rest indicated consistently reduced excitability of pyramidal cells in schizophrenia (Adams et al, 2021, Biol Psych). Two potential explanations are i) hypofunction of pyramidal NMDA receptors, and ii) greater pyramidal inhibition by inhibitory interneurons. We disambiguated these hypotheses using a dynamic causal model (DCM) in which NMDA receptors and interneuronal inhibition are explicitly parameterised, and P300 and P50 EEG paradigms from the BSNIP dataset.
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