Abstract
BackgroundTumor suppressor gene p53 expression has been reported in patients with ulcerative colitis (UC). However, the correlation between p53 expression and UC remains controversial. The aim of this meta-analysis was to investigate the association between p53 expression and different pathological types of UC.MethodsPublications were searched in the PubMed, Embase, EBSCO, Wangfang, and CNKI databases. The overall odds ratios (ORs) and their corresponding 95% confidence intervals (95% CIs) were summarized in this study.ResultsFinal 19 papers were identified in this meta-analysis, including 1068 patients with UC and 130 normal tissue samples. Immunohistochemical p53 expression was significantly higher in UC without dysplasia and carcinoma (UC group) compared to normal tissue samples (OR = 3.14, P = 0.001), higher in UC with dysplasia than in UC group (OR = 10.76, P < 0.001), and higher in UC with colorectal cancer (CRC) than in UC with dysplasia (OR = 1.69, P = 0.035). Subgroup analysis of ethnicity (UC group vs. normal tissues) showed that p53 expression was correlated with UC in Asians, but not in Caucasians. When UC with dysplasia was compared to UC group, p53 expression was linked to UC with dysplasia among both Asians and Caucasians. When UC-CRC was compared to UC with dysplasia, p53 expression was not associated with UC-CRC in both Caucasians and Asians.Conclusionsp53 expression was closely associated with UC-CRC development. p53 expression showed different ethnic characteristics among different pathological types of UC.
Highlights
Tumor suppressor gene p53 expression has been reported in patients with ulcerative colitis (UC)
Study selection The eligible publications should meet the following inclusion criteria: 1) patients were diagnosed with UC by pathological examination; 2) normal tissue samples belonged to normal control group, UC groups included UC without dysplasia/carcinoma, UC with dysplasia, and UC with colorectal cancer; 3) studies on the immunohistochemical determination of p53 protein expression provided sufficient information to determine the relationship between p53 expression and UC
Nine studies evaluated the correlation of p53 expression in UC versus normal tissue samples. 11 studies evaluated the correlation of p53 expression in UC with dysplasia versus UC without dysplasia and carcinoma. 16 studies evaluated the relationship of p53 expression in UC with carcinoma versus UC with dysplasia
Summary
Tumor suppressor gene p53 expression has been reported in patients with ulcerative colitis (UC). As one common pathological type of inflammatory bowel diseases (IBD), ulcerative colitis (UC) is characterized by a relapsing, idiopathic, and chronic inflammatory disease which usually affects the entire colon and rectum [1, 2]. The prevalence of this disease has been rising in the world, patients with UC are correlated with an increased risk of developing colorectal cancer (CRC) [3, 4]. Because the sample size of an individual study was small in UC, there were some inconsistent results with respect to p53 expression
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
