P-354: Clinical evidence of endometrial proliferation in infertile women with endometriosis

Abstract

ObjectiveThe endometriosis is an estrogen-dependent disorder that can result in infertility. The cause-effect relationship between endometriosis and infertility is controversial. A Recent retrospective multicenter analysis reported cumulative pregnancy rate was correlated with endometriosis stage, and also high frequency of endometrial polyps was detected in endometriosis. The aim of this study was to evaluate the correlation between severity of endometriosis and incidence of endometrial polyps.DesignProspective clinical study.Materials and methodsThe study population consisted of 631 infertile women, including 433 women with endometriosis (study group) and 198 women without the disease (control group). The presence of endometriosis was documented by diagnostic or therapeutic laparoscopic operation and the disease severity was scored according to the American Fertility Society classification. We confirmed the endometrial polyps by pathologic examination after hysteroscopic polypectomy.ResultsThere was no significant difference between groups with regard to age, mean duration of infertility, hormonal profiles and the other component of basic infertility work-up study. Endometrial polyps were found in 273 women (273/433, 63.0%) with endometriosis and in 59 controls (59/198, 29.8%, p= 0.0000). The incidence of endometrial polyps differed significantly according to stage of endometriosis. The incidence of endometrial polyps were 77/142 (54.2%), 58/90 (64.4%), 73/108(67.6%, p<0.05), 66/93(71.0%, p<0.05) in endometriosis stage I, II, III, and IV. Although there appeared to be a positive correlation between stage of endometriosis and incidence of endometrial polyps, significant difference was found in only endometriosis stage III and IV.ConclusionThis results suggest that positive correlation between severity of endometriosis and incidence of endometrial polyps. We would like to recommend hysteroscopy if endometriosis is detected in a woman undergoing evaluation for infertility. ObjectiveThe endometriosis is an estrogen-dependent disorder that can result in infertility. The cause-effect relationship between endometriosis and infertility is controversial. A Recent retrospective multicenter analysis reported cumulative pregnancy rate was correlated with endometriosis stage, and also high frequency of endometrial polyps was detected in endometriosis. The aim of this study was to evaluate the correlation between severity of endometriosis and incidence of endometrial polyps. The endometriosis is an estrogen-dependent disorder that can result in infertility. The cause-effect relationship between endometriosis and infertility is controversial. A Recent retrospective multicenter analysis reported cumulative pregnancy rate was correlated with endometriosis stage, and also high frequency of endometrial polyps was detected in endometriosis. The aim of this study was to evaluate the correlation between severity of endometriosis and incidence of endometrial polyps. DesignProspective clinical study. Prospective clinical study. Materials and methodsThe study population consisted of 631 infertile women, including 433 women with endometriosis (study group) and 198 women without the disease (control group). The presence of endometriosis was documented by diagnostic or therapeutic laparoscopic operation and the disease severity was scored according to the American Fertility Society classification. We confirmed the endometrial polyps by pathologic examination after hysteroscopic polypectomy. The study population consisted of 631 infertile women, including 433 women with endometriosis (study group) and 198 women without the disease (control group). The presence of endometriosis was documented by diagnostic or therapeutic laparoscopic operation and the disease severity was scored according to the American Fertility Society classification. We confirmed the endometrial polyps by pathologic examination after hysteroscopic polypectomy. ResultsThere was no significant difference between groups with regard to age, mean duration of infertility, hormonal profiles and the other component of basic infertility work-up study. Endometrial polyps were found in 273 women (273/433, 63.0%) with endometriosis and in 59 controls (59/198, 29.8%, p= 0.0000). The incidence of endometrial polyps differed significantly according to stage of endometriosis. The incidence of endometrial polyps were 77/142 (54.2%), 58/90 (64.4%), 73/108(67.6%, p<0.05), 66/93(71.0%, p<0.05) in endometriosis stage I, II, III, and IV. Although there appeared to be a positive correlation between stage of endometriosis and incidence of endometrial polyps, significant difference was found in only endometriosis stage III and IV. There was no significant difference between groups with regard to age, mean duration of infertility, hormonal profiles and the other component of basic infertility work-up study. Endometrial polyps were found in 273 women (273/433, 63.0%) with endometriosis and in 59 controls (59/198, 29.8%, p= 0.0000). The incidence of endometrial polyps differed significantly according to stage of endometriosis. The incidence of endometrial polyps were 77/142 (54.2%), 58/90 (64.4%), 73/108(67.6%, p<0.05), 66/93(71.0%, p<0.05) in endometriosis stage I, II, III, and IV. Although there appeared to be a positive correlation between stage of endometriosis and incidence of endometrial polyps, significant difference was found in only endometriosis stage III and IV. ConclusionThis results suggest that positive correlation between severity of endometriosis and incidence of endometrial polyps. We would like to recommend hysteroscopy if endometriosis is detected in a woman undergoing evaluation for infertility. This results suggest that positive correlation between severity of endometriosis and incidence of endometrial polyps. We would like to recommend hysteroscopy if endometriosis is detected in a woman undergoing evaluation for infertility.