Abstract
BackgroundSeveral studies using event-related potential (ERP) methods have reported a relationship between the cognitive dysfunction of patients with psychosis and P300 latency and amplitude. P300 follow-up studies in patients with schizophrenia receiving antipsychotic treatment revealed that the P300 amplitudes were increased while other studies showed limited changes in the P300 amplitude even after antipsychotics use.ResultsWe found that at the first presentation, all patients’ groups have significantly lower amplitude and more prolonged latency of P300 than controls. All the first-episode psychosis patients showed a significant improvement of P300 amplitude mean scores after 1 year, but with no significant change in the P300 latency. There was an inverse correlation between the patients’ PANSS scores and their P300 latency and amplitude values.ConclusionP300 amplitude and latency might be of clinical value in the evaluation of cognitive functions in the first-episode psychosis patients. The abnormalities in P300 may be improved with continuous control of psychotic symptoms with psychotropic medications.
Highlights
Several studies using event-related potential (ERP) methods have reported a relationship between the cognitive dysfunction of patients with psychosis and P300 latency and amplitude
We found that the P300 amplitude was significantly reduced compared to controls in all patient groups in comparison to the control group and that schizophrenia spectrum disorders (SSD) patients had a significantly lower score compared to both bipolar and depressive psychosis
We found that the more psychopathology the patients had according to Positive and Negative Syndrome Scale (PANSS), the worse was their performance on P300 examination
Summary
Several studies using event-related potential (ERP) methods have reported a relationship between the cognitive dysfunction of patients with psychosis and P300 latency and amplitude. Event-related potentials (ERPs) are considered cerebral responses which are linked to various psychological events. They are objective measurements reflecting cognitive functions [1, 2]. The P300 ERP component is defined as a delayed cognitive-related ERP component associated with attention and memory processes [2]. The P300 event-related brain potential is an index of endogenous cognitive processes that include directed attention and the contextual updating of working memory [3]. One of the measurements of the central nervous system activity is the P300 amplitude which happens when stimulus memory representations are generated.
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