Abstract
Two doses (100 mg / kg and 200 mg / kg po) of Heliantus annus seed extract were evaluated for memory enhancement activity compared to scopolamine-induced amnesia (1 mg / kg, ip) in mice. Piracetam (400 mg / kg i.p) was used as a standard in both models. Anticholinesterase activity was assessed as biochemical estimation. The elevated plus maze served as the simple behavioral model which has been used from decades to evaluate learning and memory in mice. The apparatus consisted of two open arms (16 cm × 5 cm) and two covered arms (16 cm × 5 cm × 12 cm) facing each other with an open roof.Acetylcholinesterase activity was measured by the method of Ellman.A photometric method for determining acetyl cholinesterase activity of tissue extracts. High doses produced a high significance (P˂0.01) and low doses produced a slight significant effect (P˂0.05) compared to the amnestic group induced by scopolamine, on day 19 and day 27. Young animals treated with doses Low and high levels showed a marked reduction of TL during day 19 and day 27 as part of learning and a noticeable reduction of TL on day 20 and day 28 as part of conservation (memory). Taken together, it indicates a significant improvement in learning and memory. The scopolamine (1 mg / kg, p.p.) injected before training significantly increased TL on days 19 and 27, indicating a decline in learning and memory. The results and statistical analysis of changes in the concentration of acetylcholine esterase (AChE) in the homogenate of the whole brain of mice isolated after administration of Heliantus annus seed extract. The low dose of Heliantus annus seed extract 100 mg/kg (p.o) produced slight significance (P˂0.05) and high dose 200 mg/ kg (p.o) produced highly significant effect (P˂0.01) on cholinesterase activity in young mice as compared to control group by using Ellman's kinetic colorimetric method. Heliantus annus seed extracts were possess memory enhancing as well as possess neuroprotective activity at 100mg/kg and 200mg/kg.
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