P287 Mean platelet volume as a predictor of severity of biliary acute pancreatitis

Abstract

<h3>Introduction</h3> Mean platelet volume (MPV) is an index of platelet activation and its role in many inflammatory conditions has been studied. Relationship of MPV with acute pancreatitis (AP) remains partially understood with many conflicting reports. The objective of this study was to assess whether MPV would be useful in predicting disease severity of biliary AP. <h3>Methods</h3> A total of 77 consecutive patients (male/female: 31/46) of biliary AP presenting to a tertiary care hospital from January 2018 to December 2020, were included in this study. Patients with pre-existing chronic pancreatitis and a previous history of AP were excluded. Demographic details and hematological parameters were recorded on the first day of hospital admission. Severity of AP was classified according to the 2012 revised Atlanta criteria. Patients with persistent organ failure of &gt; 48 h were assigned to the severe AP group and all others were included in the non-severe group. Data was analyzed using SPSS v25, with application of independent sample t-test for quantitative variables. Receiver operating characteristic curve analysis was performed to determine the accuracy of MPV for predicting disease severity. <h3>Results</h3> There were 22 patients in the severe AP group and 55 patients in the non-severe AP group. MPV was significantly lower in the severe AP group (8.60 ± 0.10 fL) as compared to the non-severe group (9.29 ± 0.10 fL) (P = 0.008). Using a cut-off value of 8.95 fL, the overall accuracy of MPV for predicting severe AP (AUC: 0.701) had a sensitivity and specificity of 77.3% and 63.6%, respectively. <h3>Conclusions</h3> This study shows that MPV at admission can be useful as a biomarker, at no additional cost, for predicting disease severity in patients of biliary acute pancreatitis.