Abstract
Chronic Pseudomonas aeruginosa (PA) infection in children with cystic fibrosis (CF) has a detrimental effect on morbidity and mortality. There is clear and well referenced guidance on the diagnostic criteria for chronic PA infection and how to treat it. However, the nebulised treatment is burdensome and the guidelines do not advise how to manage children who stop isolating PA and specifically, if the treatment should be discontinued. This is particularly important in the era of highly effective CFTR modulator therapy as monitoring lower airways is more difficult in children not productive of sputum.
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