Abstract

Population studies suggest that high body mass index (BMI) correlates with a reduced risk for death from some cancer like melanoma. The aim of our study was to evaluate the influence of high BMI on long-term overall survival (OS) in Mexican patients with advanced NSCLC. We evaluated 146 patients with advanced lung cancer (IIIB and IV) who were treated for locally advanced NSCLC. Demographic and clinical data were collected. BMI was estimated at diagnosis in routine screening evaluation before systemic treatment. They were stratified into two BMI groups ≧30kg/m2 and <30kg/m2 . Overall survival was analyzed by BMI group. Kaplan-Meier survival analysis and the log-rank test were used to calculate OS. Univariate and multivariate analysis to identify variables associated with OS was assessed using Cox regression model Baseline patient characteristics and treatment parameters were similar between high BMI and no high patients. Among the included patients, the median age was 63.39 (range: 29-86 years), 49.2 % patients were females and 50.8 % were males. High BMI was associated with improved overall survival 38 vs 25 months p=0.047. There were no difference in overall survival between patient with overweight (25–29.9 kg/m2) and normal weight (18.5-24.9 kg/m2) counterparts ( 26 vs 25 months, p = 0.67) High BMI patients in this retrospective study had significantly improved survival relative to no high BMI patients. Our data suggest that the protective effect of obesity in locally advanced NSCLC. Additional studies are needed to clarify the mechanisms and possible concomitant factors underlying the obesity in NSCLC as dietary and lifestyle interventions.

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