Abstract
Platelet-activating factor (PAF) plays a significant role in fertility. Preimplantation stage embryos produce PAF (ePAF) and this ePAF is required for development. The amount of ePAF produced by human embryos is related to pregnancy outcomes. PAFs mechanism of action is a receptor-mediated event and its presence has been reported in the developing mouse and human embryo. Exposure of preimplantation stage mouse embryos will result in higher implantation rates, birth rates and birth weights. However, the effect of such treatment on human embryos is not known.
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