Abstract
imaging was conducted followingz 12 mCi of [11 C] PIB and 60 min dynamic PET scan in 3D mode (septa retracted). Mean cortical binding potential (MCBP) was determined as previously described. Results: Pearson correlation revealed the following correlations and trends between MCBP (for amyloid) and hippocampal subvolumes: left CA2-3 r 1⁄4 -0.29 (p 1⁄4 0.05); right CA2-3 r1⁄4 -0.25 (p1⁄4 0.09); left CA1 r1⁄4 -0.20 (p1⁄4 0.18); right CA1 r 1⁄4 -0.27 (p 1⁄4 0.07). No other regional volumes were correlated with MCBP. Conclusions: In this young healthy cognitively normal population there were trends towards the same pattern seen recently in an amnestic MCI population, with significantly smaller subfield volumes in CA 2-3 and subiculum compared with controls. In our study group only 8/46 participants had elevated MCBP (> 0.18 BP). We will extend our sample to a larger and older population, which can be expected to have higher numbers of participants with elevated amyloid.
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