Abstract
Inflammation has been associated with depressive illness and treatment resistance. These advances have prompted a search for predictive biomarkers of treatment response. The Systemic Inflammation Index (SII) has shown promise as a prognostic indicator for solid malignancies and cardiovascular disease while its use in psychiatric conditions remains under-explored. In a recent randomized, double-blind, placebo-controlled trial we found that combined treatment with celecoxib (CXB) and escitalopram (ESC) was more effective in reversing treatment resistance and augmenting antidepressant response in treatment-resistant bipolar depression (TRBDD) compared to ESC plus placebo.
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