P196 THE IMPACT OF INFLAMMATORY BOWEL DISEASE SEVERITY ON HEALTH-RELATED QUALITY OF LIFE

Abstract

Few studies have examined the association between severity of inflammatory bowel disease (IBD) and humanistic burden. The current study examined the association between IBD severity and health-related quality of life (HRQoL). Data from the 2015 US National Health and Wellness Survey (N=97,700) were used to identify IBD patients, defined as those who self-reported a diagnosis of Crohn’s disease or ulcerative colitis. Respondents with IBD (n=1,020) were categorized by self-reported IBD severity: mild (n=620), moderate (n=307), and severe (n=93). Comparisons were made across IBD severity groups and a non-IBD matched control group (n=1,020); the latter identified using propensity score matching (1:1 ratio). HRQoL was assessed with SF-36v2 metrics: Mental Component Summary (MCS), Physical Component Summary (PCS), Health State Utilities Score (SF-6D), and health domain scores. Post-match, one-way omnibus ANOVAs examined whether HRQoL differed by IBD status and severity. There was a linear trend across severity cohorts: as severity increased, HRQoL decreased. Matched controls without IBD had the highest MCS and PCS scores (Means [M]=47.8; 48.4), followed by those with mild (M=45.6; 45.7), moderate (M=39.9; 39.9), and severe IBD (M=40.2; 38.7) (p<0.001). Similarly, non-IBD matched controls had the highest SF-6D scores (M=0.71), followed by those with mild (M=0.68), moderate (M=0.59), and severe IBD (M=0.58) (p<0.001). Differences on all HRQoL outcomes between those with moderate/severe IBD compared with mild IBD and non-IBD controls exceeded minimally important differences. As IBD severity increases, so does the HRQoL burden on IBD patients. Findings suggest that reducing IBD severity to even a mild level may potentially improve health-related quality of life among individuals with IBD.