Abstract
Meeting abstracts We recently identified RIG-I-like helicases (RLH) as therapeutic targets of pancreatic cancer for counteracting immunosuppressive mechanisms and apoptosis induction. Here, we investigated immunogenic consequences of RLH-induced tumour cell death. Murine pancreatic cancer cells (
Highlights
We recently identified RIG-I-like helicases (RLH) as therapeutic targets of pancreatic cancer for counteracting immunosuppressive mechanisms and apoptosis induction
dendritic cells (DC) upregulated B7 expression, which was mediated by tumourderived type I IFN, whereas TLR, RAGE or inflammasome signaling was dispensable
Tumour cell death mediated by oxaliplatin, staurosporine or mechanical disruption failed to induce DC activation, antigen uptake or cross-presentation
Summary
We recently identified RIG-I-like helicases (RLH) as therapeutic targets of pancreatic cancer for counteracting immunosuppressive mechanisms and apoptosis induction. Schnurr et al Journal for ImmunoTherapy of Cancer 2014, 2(Suppl 2):P8 http://www.immunotherapyofcancer.org/content/2/S2/P8 RIG-I-like helicases induce immunogenic cell death of pancreatic cancer cells M Schnurr1*, A Steger2, H Lohr2, H Bourhis2, S Endres2, P Duewell2
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
