Abstract
BACKGROUND CONTEXT: Advancements in diagnostic methods and biomarkers of facet arthrosis are needed as emerging motion-preserving technologies to treat spinal deformities and degenerative spinal conditions continue to develop. Currently there exists no imaging tool that facilitates a quantitative measure of facet articular cartilage integrity. We have recently validated T1rho MRI as a noninvasive, quantitative, highly reproducible biomarker of nucleus pulposus proteoglycan loss and early degenerative disc disease (DDD).
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