Abstract
Background: Cisplatin (CDDP) based chemoradiotherapy (CRT) followed by adjuvant chemotherapy for nasopharyngeal carcinoma shows poor compliance due to severe acute adverse events. However, progress in medical oncology and radiation oncology may improve the compliance.Methods: We retrospectively analyzed the completion rate, feasibility and efficacy of initial treatment consists of CRT (3 cycles of CDDP 100mg/m2 during intensity modulated radiation therapy (IMRT, 70Gy/33Fr)) and adjuvant chemotherapy (3 cycles of FP regimen (CDDP 80mg/m2 day1 and 5-fluorouracil 1000mg/m2 day1-4)) about 11 patients from February 2012 to January 2014.Results: All 11 patients completed radiation therapy without treatment breaks. During CRT, the dose of CDDP was reduced to 80mg/m2 for subsequent cycles in 6 patients. However, in 10 patients, the cumulative dose was over 200mg/m2 and mean value of all patients was 268mg/m2. Numbers of patients who received 3, 2, 1 and 0 cycles of adjuvant chemotherapy were 7, 1, 2 and 1 respectively. Severe acute toxicities (grade 3 and 4) were as follows: pharyngeal mucositis in 4 patients, dysphagia in 1 patient, aspiration in 1 patient, sepsis in 1 patient. All 11 patients achieved good local control (CR and good PR) but 1 patient relapsed with lung metastasis.Conclusion: Our protocol suggests better compliance compared with previous reports.
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