Abstract
To assess the predictivity of first-trimester uterine artery Doppler measurements for pre-eclampsia. Uterine artery Doppler findings were prospectively obtained at 11–14 weeks in 3100 singleton pregnancies. Pre-eclampsia was defined as a blood pressure > 140/90 mmHg, and proteinuria of ≥ 300 mg in 24hrs, or two readings of at least 1 + on dipstick analysis of midstream or catheter urine specimens if no 24-hour urine collection was available. There were 54 cases of pre-eclampsia (1.7%), for 16 of which (0.5%) delivery before 37 weeks was necessary. Sensitivity and specificity of different cut-offs of uterine resistance index (RI), pulsatility index (PI), bilateral diastolic notches, and their combinations for the prediction of pre-eclampsia are shown in the Table. First-trimester uterine artery Doppler has a limited usefulness for screening for pre-eclampsia in an unselected obstetric population.
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