Abstract
Background The role that neutralizing antibodies (NAbs) play in controlling viral replication during early HIV infection is not fully understood. Autologous HIV NAbs are first detected in humans several weeks after peak viremia, suggesting that they are not involved in the initial decrease in viral load. However, it is not clear if these antibodies are present at titers lower than the limit of detection of current assays. To more clearly evaluate this question, we have investigated the development of NAbs in early SIV infection using the macaque model system.
Highlights
The role that neutralizing antibodies (NAbs) play in controlling viral replication during early HIV infection is not fully understood
To more clearly evaluate this question, we have investigated the development of NAbs in early SIV infection using the macaque model system
Autologous NAb activity was detected in some SIVinfected macaques up to 10 wks earlier than typically found in HIV-infected humans, and antibody titers were an average of 10 fold greater
Summary
High-titer autologous and heterologous neutralizing antibody activity in acute SIV-infection. Address: 1R&D, Monogram Biosciences, South San Francisco, CA, USA and 2University of California, Davis, CA, USA * Corresponding author from AIDS Vaccine 2009 Paris, France. Published: 22 October 2009 Retrovirology 2009, 6(Suppl 3):P75 doi:10.1186/1742-4690-6-S3-P75. AIDS Vaccine 2009 Anna Laura Ross Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/pdf/1471-2105-10-S12-info.pdf
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