P026 Four unrelated individuals sharing a haplotype with a rear allele DQB1∗06:123

Abstract

In 2013, one laboratory from Saudi Arabia reported a rare allele of DQB1 locus to IMGT using two different cells. At our laboratory, we observed four unrelated individuals typed for DQB1 locus by RSSO as DQB1∗06:29/123. Since DQB1∗06:29/123 has the same beads reaction by RSSO, Sequence based typing for the four individuals confirmed the typing to be DQB1∗06:123. In addition, the four unrelated individuals shared the same haplotype (A∗02; B∗50; C∗06; DRB1∗15:01; DQB1∗06:123). This particular allele may be included in the common and well-documented (CWD) alleles. As per the 2012 published CWD HLA alleles an allele that is detected three times or more in unrelated individuals with a specific haplotype as discussed above should be included in the well-documented category.